S-亚硝基谷胱甘肽
S-亚硝基化
一氧化氮
还原酶
细胞生物学
炎症
细胞内
信号转导
平衡
化学
亚硝化
调节器
生物化学
生物
谷胱甘肽
酶
免疫学
半胱氨酸
有机化学
基因
出处
期刊:Biomolecules & Therapeutics
[The Korean Society of Applied Pharmacology]
日期:2018-11-01
卷期号:26 (6): 533-538
被引量:15
标识
DOI:10.4062/biomolther.2018.179
摘要
Nitric oxide (NO) mediates various physiological and pathological processes, including cell proliferation, differentiation, and inflammation. Protein S-nitrosylation (SNO), a NO-mediated reversible protein modification, leads to changes in the activity and function of target proteins. Recent findings on protein-protein transnitrosylation reactions (transfer of an NO group from one protein to another) have unveiled the mechanism of NO modulation of specific signaling pathways. The intracellular level of S-nitrosoglutathione (GSNO), a major reactive NO species, is controlled by GSNO reductase (GSNOR), a major regulator of NO/SNO signaling. Increasing number of GSNOR-related studies have shown the important role that denitrosylation plays in cellular NO/SNO homeostasis and human pathophysiology. This review introduces recent evidence of GSNO-mediated NO/SNO signaling depending on GSNOR expression or activity. In addition, the applicability of GSNOR as a target for drug therapy will be discussed in this review.
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