刺
干扰素基因刺激剂
先天免疫系统
干扰素
信号通路
医学
免疫系统
疾病
免疫学
信号转导
信号转导衔接蛋白
生物
重症监护医学
细胞生物学
内科学
航空航天工程
工程类
作者
Yang Li,Heather L. Wilson,Endré Kiss-Toth
标识
DOI:10.1186/s12950-017-0159-2
摘要
The presence of cytosolic double-stranded DNA molecules can trigger multiple innate immune signalling pathways which converge on the activation of an ER-resident innate immune adaptor named “STimulator of INterferon Genes (STING)”. STING has been found to mediate type I interferon response downstream of cyclic dinucleotides and a number of DNA and RNA inducing signalling pathway. In addition to its physiological function, a rapidly increasing body of literature highlights the role for STING in human disease where variants of the STING proteins, as well as dysregulated STING signalling, have been implicated in a number of inflammatory diseases. This review will summarise the recent structural and functional findings of STING, and discuss how STING research has promoted the development of novel therapeutic approaches and experimental tools to improve treatment of tumour and autoimmune diseases.
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