A review: Pharmaceutical excipients of solid dosage forms and characterizations

赋形剂 剂型 活性成分 材料科学 休止角 差示扫描量热法 傅里叶变换红外光谱 扫描电子显微镜 流动特性 色谱法 化学 化学工程 药理学 复合材料 医学 物理 热力学 工程类 机械
作者
Iyan Sopyan,Ni Made Widya Sukma Santi,Alif Virisy Berlian,Noer Erin Meilina,Qisti Fauza,Restu Amelia Apriyandi
出处
期刊:International Journal of Research in Pharmaceutical Sciences [GP Innovations Pvt. Ltd.]
卷期号:11 (2): 1472-1480 被引量:4
标识
DOI:10.26452/ijrps.v11i2.2020
摘要

Excipients play an important role in formulating dosage forms. Exertion is empowered to help manufacture, provide, or collect dosage forms. Although considered pharmacological, excipients may consider a drug, due to chemical or physical interactions with the composition of the drug. Excipients have many functions in pharmaceutical dosage forms, including enhancing active ingredients in dosage forms, assisting active ingredients, disintegration, lubricants, binders, and suppliers. Each excipient has different characteristics. In this review, a library of studios is provided relating to the function, function, and content of solid excipients in a solid sedan. Various choices can be used on different compositions; resulting, this difference is also different. In this example, describe the types of excipients that can be used for various components in solid preparations that can be used in the formulation of solid preparations and select the right type of excipient according to the character of the desired solid preparation. In this review also presented a method, combining in and characterizing solid excipients to see the quality. The most commonly used methods for analysis of solid excipients are flow properties, compressibility index, Hausner index ratios, and angle of repose, while the instrumentation commonly used is Fourier transform infrared spectroscopy (FTIR), H and C-Nucleo magnetic resonance (H-CNMR), Scanning electron microscopy (SEM), Particle size analysis (PSA), X-ray diffraction (XRDP) and Differential scanning calorimeter (DSC).
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