Research status of granulocyte transfusions

Neutrophils are one of the most important cells in the body against bacterial and fungal infections. Patients with acute leukemia who received radiotherapy, chemotherapy or hematopoietic stem cell transplantation (HSCT), and with severe aplastic anemia (SAA), can occur with severe neutropenia that lasts longer, during which severe bacterial and fungal infections can occur. Despite the use of broad-spectrum antibacterial agents and granulocyte colony-stimulating factor (G-CSF), severe infections during neutropenia still lead to prolonged hospital stay, organ damage, and even death of patients. The recovery of bone marrow granulocyte hematopoiesis is the key to successful infection control. For patients with severe infections of granulocytopenia, especially agranulocytosis, granulocyte transfusions is a means of adjuvant therapy. In order to understand the role and indications of granulocyte transfusions, the article intends to introduce the collection technology of granulocyte, therapeutic effect and adverse reactions of granulocyte transfusions. Key words: Neutropenia; Agranulocytosis; Granulocyte colony-stimulating factors; Infection; Granulocyte transfusions; Neutrophil dysfunction