癌细胞
免疫系统
血管生成
癌症研究
癌症
转移
生物
炎症体
启动(农业)
免疫学
背景(考古学)
炎症
遗传学
植物
发芽
古生物学
作者
Cédric Rébé,François Ghiringhelli
出处
期刊:Cancers
[MDPI AG]
日期:2020-07-04
卷期号:12 (7): 1791-1791
被引量:144
标识
DOI:10.3390/cancers12071791
摘要
Within a tumor, IL-1β is produced and secreted by various cell types, such as immune cells, fibroblasts, or cancer cells. The IL1B gene is induced after "priming" of the cells and a second signal is required to allow IL-1β maturation by inflammasome-activated caspase-1. IL-1β is then released and leads to transcription of target genes through its ligation with IL-1R1 on target cells. IL-1β expression and maturation are guided by gene polymorphisms and by the cellular context. In cancer, IL-1β has pleiotropic effects on immune cells, angiogenesis, cancer cell proliferation, migration, and metastasis. Moreover, anti-cancer treatments are able to promote IL-1β production by cancer or immune cells, with opposite effects on cancer progression. This raises the question of whether or not to use IL-1β inhibitors in cancer treatment.
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