染色质
生物
核蛋白
转录调控
计算生物学
抄写(语言学)
转录因子
功能(生物学)
小RNA
细胞生物学
基因表达调控
遗传学
DNA
基因
语言学
哲学
作者
Ty C. Voss,Gordon L. Hager
摘要
The interaction of regulatory proteins with the complex nucleoprotein structures that are found in mammalian cells involves chromatin reorganization at multiple levels. Mechanisms that support these transitions are complex on many timescales, which range from milliseconds to minutes or hours. In this Review, we discuss emerging concepts regarding the function of regulatory elements in living cells. We also explore the involvement of these dynamic and stochastic processes in the evolution of fluctuating transcriptional activity states that are now commonly reported in eukaryotic systems.
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