免疫疗法
表观遗传学
合理设计
小分子
癌症
癌症治疗
癌症免疫疗法
计算生物学
表观遗传疗法
免疫检查点
免疫系统
癌症研究
生物
免疫学
DNA甲基化
基因
基因表达
生物化学
遗传学
作者
Clemens Zwergel,Rossella Fioravanti,Antonello Mai
标识
DOI:10.1016/j.drudis.2022.103435
摘要
Programmed death-ligand 1 (PD-L1) is an immune checkpoint protein the overexpression of which results in an inhibitory signal that induces T cell exhaustion responsible for immune escape in tumors. Immunotherapy strategies targeting the PD-L1 pathway have achieved remarkable success in treating various types of cancer. More recently, numerous advances in understanding the complex PD-L1 biology have been made, and the first small-molecule inhibitors have been described in the literature. In this review, we highlight the most promising recent advances in understanding the complex regulation mechanisms focusing on small-molecule modulators, which could be used in rational therapy combinations with other epigenetic chemotherapeutic agents.
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