Hesperetin Nanoparticle Targeting Neutrophils for Enhanced TBI Therapy (Adv. Funct. Mater. 43/2022)

Hesperetin Nanoparticles In article number 2205787, Xiangtong Zhang, Liao Cui, Chunming Huang, Longguang Tang, and co-workers design a hesperetin nanoparticle that targets neutrophils, T-Hes, catalyzed by myeloperoxidase secreted by neutrophils, which can effectively identify inflammatory neutrophils and quickly gather in the injured area after traumatic brain injury. The sustained release of hesperetin by T-Hes shows great advantages in anti-inflammatory treatment, reducing brain edema and improving neurological function.