Understanding battery capacity degradation is instrumental for designing modern electric vehicles. In this paper, a Semi-Empirical Model for predicting the CapacityLoss of Lithium-ion batteries during Cycling and Calendar Aging is developed. In order to predict the Capacity Loss with a high accuracy, battery operation datafrom different test conditions and different Lithium-ion batteries chemistries were obtained from literature for parameter optimization (fitting). The obtained modelswere then compared to experimental data for validation. Our results show that the average error between the estimated Capacity Loss and measured Capacity Loss isless than 1.5% during Cycling Aging, and less than 2% during Calendar Aging. An electric mining dumper, with simulated duty cycle data, is considered as an application example.