生物标志物
餐后
医学
血液取样
内科学
病理生理学
内分泌学
阿尔茨海默病
餐食
疾病
β淀粉样蛋白
胃肠病学
生理学
生物
生物化学
胰岛素
作者
Hanna Huber,Nicholas J. Ashton,Alina Schieren,Laia Montoliu‐Gaya,Guglielmo Di Molfetta,Wagner S. Brum,Juan Lantero‐Rodriguez,Lana Grötschel,Birgit Stoffel‐Wagner,Martin Coenen,Leonie Weinhold,Massachusetts Schmid,Kaj Blennow,Peter Stehle,Henrik Zetterberg,Marie‐Christine Simon
摘要
Abstract INTRODUCTION Blood biomarkers accurately identify Alzheimer's disease (AD) pathophysiology and axonal injury. We investigated the influence of food intake on AD‐related biomarkers in cognitively healthy, obese adults at high metabolic risk. METHODS One‐hundred eleven participants underwent repeated blood sampling during 3 h after a standardized meal (postprandial group, PG). For comparison, blood was sampled from a fasting subgroup over 3 h (fasting group, FG). Plasma neurofilament light (NfL), glial fibrillary acidic protein (GFAP), amyloid‐beta (Aβ) 42/40, phosphorylated tau (p‐tau) 181 and 231, and total‐tau were measured via single molecule array assays. RESULTS Significant differences were found for NfL, GFAP, Aβ42/40, p‐tau181, and p‐tau231 between FG and PG. The greatest change to baseline occurred for GFAP and p‐tau181 (120 min postprandially, p < 0.0001). CONCLUSION Our data suggest that AD‐related biomarkers are altered by food intake. Further studies are needed to verify whether blood biomarker sampling should be performed in the fasting state. Highlights Acute food intake alters plasma biomarkers of Alzheimer's disease in obese, otherwise healthy adults. We also found dynamic fluctuations in plasma biomarkers concentration in the fasting state suggesting physiological diurnal variations. Further investigations are highly needed to verify if biomarker measurements should be performed in the fasting state and at a standardized time of day to improve the diagnostic accuracy.
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