丸(消化)
冰崩解
哺乳期
医学
子宫炎
牧群
动物科学
不利影响
牛奶热
低钙血症
口服
钙
内科学
内分泌学
兽医学
生物
怀孕
遗传学
作者
C.R. Seely,Christopher J. Wilbur,Kuan Fang,J.A.A. McArt
标识
DOI:10.3168/jds.2023-23541
摘要
Supplementation of oral Ca via blanket administration of an oral Ca bolus at 0 and 24 h post calving has shown limited success in increasing production and minimizing adverse health events. Recent evidence that reductions in blood Ca at 4 DIM are more closely associated with negative outcomes than hypocalcemia at 0 to 24 h postpartum might explain this lack of Ca bolus efficacy. Therefore, our primary objective was to explore the effect of delayed oral Ca bolus supplementation on milk production, with secondary objectives of exploring the effect on disease incidence and postpartum blood Ca dynamics. We conducted a randomized controlled trial on multiparous Holstein cows (n = 998) from 4 herds in NY. At calving, cows were randomly assigned to 1 of 3 treatment groups: 1) control; no supplemental Ca at or around parturition (CON; n = 343), 2) conventional bolus; an oral Ca bolus containing 43 g Ca at calving and 24 h later (BOL-C; n = 330), or 3) delayed bolus; an oral Ca bolus containing 43 g Ca at 48 and 72 h post-calving (BOL-D; n = 325). We created generalized linear mixed models to analyze differences in milk yield for the first 10 wk of lactation and serum total Ca (tCa) at 1 and 4 DIM between treatment groups; multivariable Poisson regression models were used to analyze adverse event outcomes (metritis, displaced abomasum, herd removal, or a combination of one or more of the 3) in the first 30 DIM. Milk yield increased by week and was not affected by treatment. However, a treatment by parity group interaction for milk yield showed that parity 3 BOL-D cows produced more milk than parity 3 BOL-C or CON cows (BOL-D = 52.0 kg/d, 95% confidence interval [50.6, 53.4] kg/d, BOL-C = 47.9 [46.3, 49.5] kg/d, CON = 49.8 [48.2, 51.2] kg/d). The incidence of adverse heath events was similar between treatments (BOL-D = 3.7%, BOL-C = 3.7%, CON = 3.6%). Serum tCa was lower at 1 than 4 DIM, and there was no difference in tCa between treatment groups. Our findings suggest that delaying oral Ca bolus supplementation has limited impact on blood Ca concentrations but may be beneficial to cohorts of cows as a targeted prophylactic supplement to support milk production.
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