医学
溃疡性结肠炎
疾病
表观遗传学
炎症性肠病
免疫学
生物信息学
自身抗体
病理
抗体
基因
遗传学
生物
作者
Gemma Caliendo,Giovanna D’Elia,Jasmine Singh,Luana Passariello,Luisa Albanese,Anna Maria Molinari,Maria Teresa Vietri
标识
DOI:10.1016/j.advms.2023.09.010
摘要
In this review, we have summarized the existing knowledge of ulcerative colitis (UC) markers based on current literature, specifically, the roles of potential new biomarkers, such as circulating, fecal, genetic, and epigenetic alterations, in UC onset, disease activity, and in therapy response. UC is a complex multifactorial inflammatory disease. There are many invasive and non-invasive diagnostic methods in UC, including several laboratory markers which are employed in diagnosis and disease assessment; however, colonoscopy remains the most widely used method. Common laboratory abnormalities currently used in the clinical practice include inflammation-induced alterations, serum autoantibodies, and antibodies against bacterial antigens. Other new serum and fecal biomarkers are supportive in diagnosis and monitoring disease activity and therapy response; and potential salivary markers are currently being evaluated as well. Several UC-related genetic and epigenetic alterations are implied in its pathogenesis and therapeutic response. Moreover, the use of artificial intelligence in the integration of laboratory biomarkers and big data could potentially be useful in clinical translation and precision medicine in UC management.
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