化学
荧光
膜片钳
钙通道
钙
生物物理学
钙显像
L型钙通道
生物化学
有机化学
受体
光学
物理
生物
作者
Carlotta Borgarelli,Yvonne E. Klingl,Abril Escamilla‐Ayala,C. Scarponi,Rita Maria Laura La Rovere,Katarina Stoklund Dittlau,Geert Bultynck,Maurilio Sampaolesi,Matthias Schoenberger,Sebastian Munck,Ludo Van Den Bosch,Wim M. De Borggraeve,Ermal Ismalaj
标识
DOI：10.1021/acs.jmedchem.4c00565
摘要
Upregulation of L-type calcium channels (LTCCs) is implicated in a range of cardiovascular and neurological disorders. Therefore, the development of toolboxes that unlock fast imaging protocols in live cells is coveted. Herein, we report a library of first-in-class far-red small-molecule-based fluorescent ligands (FluoDiPines), able to target LTCCs. All fluorescent ligands were evaluated in whole-cell patch-clamp and live-cell Ca
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