Recent advances on transport and transformation mechanism of nanoplastics in lung cells

Microplastics (MPs) are solid plastic particles less than or equal to 5 mm in size that are insoluble in water, and when the diameter is further reduced to <1 micrometer (μm), we call them nanoplastics (NPs). MPs and NPs are widely present in the atmosphere, and plastic particles have also been detected in the sputum of patients with respiratory diseases. This warns us that these tiny plastic particles are a potential threat to human respiratory health. The lungs, as the main organs of the respiratory system, are more likely to be adversely affected by inhaled NPs. However, the mechanism of transport and transformation of NPs in the lung is not clear, so our review mainly focuses on a series of effects and mechanisms of NPs on lung cells through absorption, distribution, metabolism, excretion (ADME) after inhalation into the human body. The most commonly used models in these experimental studies we focus on are A549 and BEAS-2B cells, which are used to model the lung cell response to plastic particles. In addition, we also summarize some shortcomings of these experiments and prospects for future studies, hoping to provide further clues for future studies and contribute to the prevention of related hazards and diseases.