医学
胰腺导管腺癌
比例危险模型
旁侵犯
接收机工作特性
危险分层
内科学
肿瘤科
对数秩检验
腺癌
放射科
人工智能
胰腺癌
癌症
计算机科学
作者
Jieyu Yu,Chengwei Chen,Mingzhi Lu,Xu Fang,Jing Li,Mengmeng Zhu,Na Li,Xiaohan Yuan,Yaxing Han,Li Wang,Jianping Lu,Chengwei Shao,Yun Bian
标识
DOI:10.1097/js9.0000000000001604
摘要
Background: Extrapancreatic perineural invasion (EPNI) increases the risk of postoperative recurrence in pancreatic ductal adenocarcinoma (PDAC). This study aimed to develop and validate a computed tomography (CT)-based, fully automated preoperative artificial intelligence (AI) model to predict EPNI in patients with PDAC. Methods: The authors retrospectively enrolled 1065 patients from two Shanghai hospitals between June 2014 and April 2023. Patients were split into training ( n =497), internal validation ( n =212), internal test ( n =180), and external test ( n =176) sets. The AI model used perivascular space and tumor contact for EPNI detection. The authors evaluated the AI model’s performance based on its discrimination. Kaplan–Meier curves, log-rank tests, and Cox regression were used for survival analysis. Results: The AI model demonstrated superior diagnostic performance for EPNI with 1-pixel expansion. The area under the curve in the training, validation, internal test, and external test sets were 0.87, 0.88, 0.82, and 0.83, respectively. The log-rank test revealed a significantly longer survival in the AI-predicted EPNI-negative group than the AI-predicted EPNI-positive group in the training, validation, and internal test sets ( P <0.05). Moreover, the AI model exhibited exceptional prognostic stratification in early PDAC and improved assessment of neoadjuvant therapy’s effectiveness. Conclusion: The AI model presents a robust modality for EPNI diagnosis, risk stratification, and neoadjuvant treatment guidance in PDAC, and can be applied to guide personalized precision therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI