车站3
重编程
癌症研究
肿瘤微环境
癌症
转移
STAT蛋白
免疫疗法
血管生成
医学
药物发现
生物
计算生物学
生物信息学
信号转导
细胞
肿瘤细胞
内科学
细胞生物学
遗传学
作者
Yamei Hu,Zigang Dong,Kangdong Liu
标识
DOI:10.1186/s13046-024-02949-5
摘要
Abstract Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor involved in almost all cancer hallmark features including tumor proliferation, metastasis, angiogenesis, immunosuppression, tumor inflammation, metabolism reprogramming, drug resistance, cancer stemness. Therefore, STAT3 has become a promising therapeutic target in a wide range of cancers. This review focuses on the up-to-date knowledge of STAT3 signaling in cancer. We summarize both the positive and negative modulators of STAT3 together with the cancer hallmarks involving activities regulated by STAT3 and highlight its extremely sophisticated regulation on immunosuppression in tumor microenvironment and metabolic reprogramming. Direct and indirect inhibitors of STAT3 in preclinical and clinical studies also have been summarized and discussed. Additionally, we highlight and propose new strategies of targeting STAT3 and STAT3-based combinations with established chemotherapy, targeted therapy, immunotherapy and combination therapy. These efforts may provide new perspectives for STAT3-based target therapy in cancer.
科研通智能强力驱动
Strongly Powered by AbleSci AI