Advances in Non-Enzymatic electrochemical materials for H2O2 sensing

With the progression of society, an increasing emphasis on physical well-being and environmental safety has driven extensive research into technologies closely aligned with human health and environmental protection. Hydrogen peroxide (H2O2), a representative reactive oxygen species (ROS), serves as one of the products resulting from the single electron reduction of oxygen in organisms, playing a crucial role in cell signaling and maintaining internal stability. Relevant alterations of H2O2 concentrations have been implicated in the pathogenesis of various diseases, including diabetes and cancer. Moreover, the utilization of H2O2 is widely prevalent in various industries including chemical, pharmaceutical, and food sectors. However, the repetitive or uncontrolled utilization of H2O2 engenders deleterious implications for human well-being and environmental integrity. Therefore, there is immense significance in exploring a simple yet effective method for real-time and quantitative detection of H2O2 in living cells and actual samples. The use of nanocatalysts as sensing materials in the electrochemical detection method has garnered significant attention from researchers due to their operational simplicity, high sensitivity, cost-effectiveness, and facile miniaturization. However, there remains a dearth of comprehensive reviews on the electrochemical detection of H2O2 utilizing nanomaterials. In this paper, we focus on summarizing contemporary techniques for H2O2 detection with a specific emphasis on electrochemical detection methods, and highlighting the significant advancements in the field of electrochemical detection of H2O2 nanomaterials while also providing insights into future developments.