再生(生物学)
生物相容性
血管
血管组织
血管平滑肌
材料科学
维管束
体内
静电纺丝
动脉
生物医学工程
化学
医学
细胞生物学
外科
生物
内科学
平滑肌
植物
复合材料
生物技术
冶金
聚合物
作者
Wenxin Ma,Zhuo Liu,Tonghe Zhu,Liming Wang,Juan Du,Kun Wang,Chen Xu
标识
DOI:10.1002/adhm.202302676
摘要
Natural blood vessels have complete functions, including elasticity, compliance, and excellent antithrombotic properties because of their mature structure. To replace damaged blood vessels, vascular grafts should perform these functions by simulating the natural vascular structures. Although the structures of natural blood vessels have been thoroughly explored, constructing a small-diameter vascular graft that matches the mechanical and biological properties of natural blood vessels remains a challenge. We fabricated a hierarchical vascular graft by electrospinning, braiding, and thermally induced phase separation (TIPS) and named it EBT vascular graft (EBTVG) to simulate the structure of natural blood vessels. The internal electrospun structure facilitated the adhesion of endothelial cells, thereby accelerating endothelialization. The intermediate PLGA fabric exhibited excellent mechanical properties, which allowed it to maintain its shape during long-term transplantation and prevent graft expansion. The external macroporous structure is beneficial for cell growth and infiltration. Blood vessel remodeling aims to combine a structure that promotes tissue regeneration with anti-inflammatory materials. The results in vitro demonstrated that the EBTVG had matched the mechanical properties, reliable cytocompatibility, and the strongest endothelialization in situ. The results in vitro and replacement of the resected artery in vivo suggested that the EBTVG combined different structural advantages with biomechanical properties and reliable biocompatibility, significantly promoting the stabilization and regeneration of vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs), as well as stabilizing the blood microenvironment . This article is protected by copyright. All rights reserved.
科研通智能强力驱动
Strongly Powered by AbleSci AI