海马体
海马结构
冲程(发动机)
腺苷
神经保护
神经科学
医学
神经发生
药理学
心理学
内科学
机械工程
工程类
作者
Lingkun Zhang,Li Liu,Qingpeng Liu,Yiquan Zhang,Ziqing Li,Haoming Xu,Weiwei Bai,Yajun Guo,Dandan Zhang,Zhendong Chen,Kun Xia,Chu-Hua Li,Junbo Ge,Yan‐Qing Guan
标识
DOI:10.1016/j.colsurfb.2024.113746
摘要
Ischemic stroke is a neurological disease that leads to brain damage and severe cognitive impairment. In this study, extracellular vesicles(Ev) derived from mouse hippocampal cells (HT22) were used as carriers, and adenosine (Ad) was encapsulated to construct Ev-Ad to target the damaged hippocampus. The results showed that, Ev-Ad had significant antioxidant effect and inhibited apoptosis. In vivo, Ev-Ad reduced cell death and reversed inflammation in hippocampus of ischemic mice, and improved long-term memory and learning impairment by regulating the expression of the A1 receptor and the A2A receptor in the CA1 region. Thus, the developmental approach based on natural carriers that encapsulating Ad not only successfully restored nerves after ischemic stroke, but also improved cognitive impairment in the later stage of ischemic stroke convalescence. The development and design of therapeutic drugs provides a new concept and method for the treatment of cognitive impairment in the convalescent phase after ischemic stroke.
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