铱
光动力疗法
光化学
光敏剂
共价键
材料科学
吸收(声学)
光催化
共轭体系
可见光谱
聚合物
化学
光电子学
催化作用
有机化学
复合材料
作者
Xuanjun Zhang,Zixiang Wei,Jintong Guo,Jinxiao Lyu,Bingzhe Wang,Gang Wang,Chunfei Wang,Liqiang Zhou,Zhen Yuan,Guichuan Xing,Changfeng Wu,Xuanjun Zhang
标识
DOI:10.1038/s41467-023-43890-z
摘要
Abstract Practical photodynamic therapy calls for high-performance, less O 2 -dependent, long-wavelength-light-activated photosensitizers to suit the hypoxic tumor microenvironment. Iridium-based photosensitizers exhibit excellent photocatalytic performance, but the in vivo applications are hindered by conventional O 2 -dependent Type-II photochemistry and poor absorption. Here we show a general metallopolymerization strategy for engineering iridium complexes exhibiting Type-I photochemistry and enhancing absorption intensity in the blue to near-infrared region. Reactive oxygen species generation of metallopolymer Ir-P1 , where the iridium atom is covalently coupled to the polymer backbone, is over 80 times higher than that of its mother polymer without iridium under 680 nm irradiation. This strategy also works effectively when the iridium atom is directly included ( Ir-P2 ) in the polymer backbones, exhibiting wide generality. The metallopolymer nanoparticles exhibiting efficient O 2 •− generation are conjugated with integrin αvβ3 binding cRGD to achieve targeted photodynamic therapy.
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