氯胺酮
扣带回前部
扁桃形结构
抗抑郁药
心理学
静息状态功能磁共振成像
后扣带
安慰剂
神经科学
腹侧纹状体
海马体
萧条(经济学)
纹状体
医学
麻醉
皮质(解剖学)
认知
多巴胺
替代医学
病理
经济
宏观经济学
作者
Matthew Burrows,Vasileia Kotoula,Ottavia Dipasquale,Argyris Stringaris,Mitul A. Mehta
标识
DOI:10.1177/02698811231189432
摘要
Background: Resting state connectivity studies link ketamine’s antidepressant effects with normalisation of the brain connectivity changes that are observed in depression. These changes, however, usually co-occur with improvement in depressive symptoms, making it difficult to attribute these changes to ketamine’s effects per se. Aims: Our aim is to examine the effects of ketamine in brain connectivity, 2 h after its administration in a cohort of volunteers with remitted depression. Any significant changes observed in this study could provide insight of ketamine’s antidepressant mechanism as they are not accompanied by symptom changes. Methods: In total, 35 participants with remitted depression (21 females, mean age = 28.5 years) participated in a double-blind, placebo-controlled study of ketamine (0.5 mg/kg) or saline. Resting state scans were acquired approximately 2 h after the ketamine infusion. Brain connectivity was examined using a seed-based approach (ventral striatum, amygdala, hippocampus, posterior cingulate cortex and subgenual anterior cingulate cortex (sgACC)) and a brain network analysis (independent component analysis). Results: Decreased connectivity between the sgACC and the amygdala was observed approximately 2 h after the ketamine infusion, compared to placebo ( p FWE < 0.05). The executive network presented with altered connectivity with different cortical and subcortical regions. Within the network, the left hippocampus and right amygdala had decreased connectivity ( p FWE < 0.05). Conclusions: Our findings support a model whereby ketamine would change the connectivity of brain areas and networks that are important for cognitive processing and emotional regulation. These changes could also be an indirect indicator of the plasticity changes induced by the drug.
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