间充质干细胞
医学
移植
炎症
伤口愈合
败血症
细胞疗法
干细胞疗法
诱导多能干细胞
干细胞
免疫学
药理学
癌症研究
生物信息学
病理
细胞生物学
生物
内科学
胚胎干细胞
生物化学
基因
作者
Lijun Wu,Wei Lin,Jian-Jiang Liu,Weixin Chen,Wenjun He,Songliu Yuan,Ling Xiao,Ke Li
出处
期刊:World Journal of Stem Cells
[Baishideng Publishing Group Co (World Journal of Stem Cells)]
日期:2023-07-26
卷期号:15 (7): 713-733
标识
DOI:10.4252/wjsc.v15.i7.713
摘要
Acute pancreatitis (AP) often leads to a high incidence of cardiac injury, posing significant challenges in the treatment of severe AP and contributing to increased mortality rates. Mesenchymal stem cells (MSCs) release bioactive molecules that participate in various inflammatory diseases. Similarly, extracellular vesicles (EVs) secreted by MSCs have garnered extensive attention due to their comparable anti-inflammatory effects to MSCs and their potential to avoid risks associated with cell transplantation. Recently, the therapeutic potential of MSCs-EVs in various inflammatory diseases, including sepsis and AP, has gained increasing recognition. Although preclinical research on the utilization of MSCs-EVs in AP-induced cardiac injury is limited, several studies have demonstrated the positive effects of MSCs-EVs in regulating inflammation and immunity in sepsis-induced cardiac injury and cardiovascular diseases. Furthermore, clinical studies have been conducted on the therapeutic application of MSCs-EVs for some other diseases, wherein the contents of these EVs could be deliberately modified through prior modulation of MSCs. Consequently, we hypothesize that MSCs-EVs hold promise as a potential therapy for AP-induced cardiac injury. This paper aims to discuss this topic. However, additional research is essential to comprehensively elucidate the underlying mechanisms of MSCs-EVs in treating AP-induced cardiac injury, as well as to ascertain their safety and efficacy.
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