Research Progress of Tumor Microenvironment-responsive Anti-tumor Nano-drug Carriers

Cancer is the most serious disease threatening human health at present, and the incidence and mortality of cancer in China ranks first in the world. Chemotherapy is an important means to treat cancer in clinic. However, many traditional small molecule chemotherapy drugs have some defects such as poor solubility, low bioavailability and great toxic and side effects. Small molecule drugs have the disadvantages of low bioavailability, such as rapid metabolism in vivo, short half-life and rapid decrease of in vivo concentration, which affects the therapeutic effect. Therefore, repeated administration is needed to improve the drug concentration. (NDS) can deliver drugs to cancer sites to improve distribution specificity, increase internalization and intracellular drug delivery, minimize adverse side effects and improve drug efficacy. In this paper, the concept, types and drug release of nano-drug carriers are expounded, and the application of nano-drug carriers in cancer treatment is analyzed by taking polymer micelle drug carriers as an example.