吡咯烷
哌啶
分子间力
双功能
化学
发散合成
药物发现
立体化学
组合化学
联轴节(管道)
有机化学
分子
催化作用
材料科学
生物化学
冶金
作者
Jeewani Poornima Ariyarathna,Prabagar Baskaran,Akanksha Chhikara,Navdeep Kaur,Alex M. Nguyen,Shashini M. Premathilaka,Michelle Mae Huynh,Jonathon Trieu Truong,Wei Li
摘要
N-heterocycles are privileged pharmaceutical scaffolds in drug discovery and development. We disclose here divergent intermolecular coupling strategies that can access diverse N-heterocycles directly from olefins. The radical-to-polar mechanistic switching is key for the divergent cyclization processes. These distinctive annulations result in the coupling of alkenes with simple bifunctional reagents for divergent N-heterocycle syntheses.
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