胎盘形成
流产
怀孕
人类白细胞抗原
免疫系统
反复流产
早孕损失
免疫学
HLA-G
不育
医学
流产
生物
胎儿
抗原
胎盘
遗传学
作者
Greta Barbaro,Annalisa Inversetti,Martina Cristodoro,Carlo Ticconi,Giovanni Scambia,Nicoletta Di Simone
摘要
Placentation is an immunological compromise where maternal immune system cells and trophoblastic cells interact to reach an equilibrium condition. Although the cross talk between the two systems is complex and not completely understood, Human Leukocyte Antigen G (HLA-G), expressed on trophoblastic cell surfaces, seems to be one of the main molecules involved in the modulation of both local and systemic maternal immune response. The prevalence of recurrent pregnancy loss (RPL), probably underestimated, is 5% of all women who achieve pregnancy, and about 40-60% percent of RPL cases are unexplained. There is an immunological analogy between allograft rejection and miscarriage, and the purpose of this review is to describe how the HLA-G pathway alterations are involved in disrupting the immunologic balance and in increasing the risk of recurrent pregnancy loss.
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