Ease to Challenges in Achieving Successful Synthesized Schiff Base, Chirality, and Application as Antibacterial Agent

This study reports how to overcome the challenges experienced in achieving successful synthesized Schiff base via types of Schiff base (chiral and achiral), synthesis, nature of products, and its antibacterial applications. Schiff base is a versatile ligand which is useful in asymmetric reactions to prepare chiral catalysts. It is also used in symmetric reactions to prepare achiral compounds. In line with the achiral compounds, conventional (room temperature and refluxing) and microwave irradiation methods are the two main types of methods to synthesize achiral Schiff base as reported in this review. Among various experimental approaches, this study supports the green chemistry microwave approach to synthesize Schiff base because of its benefits environmental sustainability. Problems relating to the nature of products formed from the synthesized Schiff bases were examined and resolved. Herein, the products could either be solid (crystals, powder, and precipitate), oily, or viscous (sticky) products. Some familiar characterization techniques used to identify and confirm the successful syntheses of Schiff bases, such as solubility test, melting point (MP), Fourier transform infrared (FTIR), ultraviolet‐visible (UV‐Vis), and nuclear magnetic resonance (NMR, 1 H NMR, and 13 C NMR), were discussed. In addition, the antibacterial studies on Schiff base and corresponding metal complexes confirmed their biological relevance to the human.