Comparative Analysis of Animal Models in Wound Healing Research and the Utility for Humanized Mice Models

Significance: The rise of chronic nonhealing lower extremity wounds among aging, diabetic, obese, and cardiovascular patients has surged. Despite a decade of drug testing in preclinical animal models, few federally approved therapies have emerged. This translational gap raises concerns about the efficacy of current wound healing models and the need for improved research development.