Design, Synthesis, and Anti-Proliferative Activity of Some New Quinoxaline Containing 1,2,4-Thiadiazoles Amide Hybrids

A series of new quinoxaline-1,2,4-thiadiazoles amide hybrids has been synthesized and evaluated for their anti-proliferative activity on four different human cancer cell lines including HeLa (breast), A549 (lung), MCF-7 (breast), and HEK-293 (embryonic kidney) using etoposide as a standard drug. Three synthesized compounds exhibit promising anticancer activity. One of those demonstrates higher potency against all cell lines than etoposide. Two products exhibit promising inhibitory activity over tyrosine kinase EGFR.