医学
慢性阻塞性肺病
纤维蛋白原
恶化
内科学
部分凝血活酶时间
平均血小板体积
凝血酶原时间
胃肠病学
白细胞
前瞻性队列研究
血小板
慢性阻塞性肺疾病急性加重期
心脏病学
作者
Lian-Kuan Chen,Wanghong Xu,Juanxia Chen,Huifang Zhang,Xiaobo Huang,Li-Ting Ma,Genggeng Yu,Yan-Jun Zhou,Bin Ma,Chao Chen,Yanhong Liu,Xiaoyong Ma
出处
期刊:Heart & Lung
[Elsevier]
日期:2023-01-01
卷期号:57: 54-58
被引量:1
标识
DOI:10.1016/j.hrtlng.2022.08.013
摘要
There is limited research on clinical indicators for clinicians to judge the hypercoagulability of COPD patients.The aim in this study was to evaluate the level changes of fibrinogen (FIB), d-dimer (D-D), and mean platelet volume (MPV) in plasma during the stable phase of chronic obstructive pulmonary disease (COPD), as compared with acute exacerbation of COPD (AECOPD).A total of 240 patients admitted with COPD in our hospital and 60 healthy people were enrolled in this prospective study using data from August 2016 to August 2017. Patients were allocated to AECOPD or stable COPD group. The levels of white blood cell (WBC) count, absolute neutrophil counts (NEU%), activated partial thromboplastin time (APTT), prothrombin time (PT), and hypoxia inducible factor-1(HIF-1) were detected. The MPV, D-D, and the FIB level were also determined and compared between groups.The WBC count, NEU%, FIB, and D-D were significantly higher in the AECOPD group than in the stable COPD group and the healthy group (P < 0.05), while the MPV, APTT and PT was significantly lower in the AECOPD group than in the stable COPD group and the healthy group (P < 0.05). Additionally, MPV was significantly negatively correlated with WBC count (r=-0.798) and NEU% (r=-0.749) in the AECOPD group (P < 0.05); and the percentage of forced expiratory volume in one second (FEV1) in the predicted value was significantly negatively correlated with D-D (r=-0.891) and FIB (r=-0.656) (P <0.05).We demonstrated that, for patients hospitalized for exacerbation of COPD, MPV may indeed be a valid indicator of inflammation and a marker of thrombosis.
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