肺癌
淋巴
化学
肺
纳米颗粒
癌症研究
材料科学
病理
医学
纳米技术
内科学
作者
Hongbin Wang,Xiaona Li,Jing Wang,Jiannan Wang,Hongyan Zou,Xuesong Hu,Lei Yang,Penghui Shen,Ao Rong,Kaiqi Wang,Yingbo Li,Jie Yang,Kai Wang,Lili Yang,Linzhi Wu,Xilin Sun
出处
期刊:Nano Letters
[American Chemical Society]
日期:2023-03-22
卷期号:23 (7): 2964-2973
被引量:2
标识
DOI:10.1021/acs.nanolett.3c00354
摘要
Recent advances in intratracheal delivery strategies have sparked considerable biomedical interest in developing this promising approach for lung cancer diagnosis and treatment. However, there are very few relevant studies on the behavior and mechanism of imaging nanoparticles (NPs) after intratracheal delivery. Here, we found that nanosized perfluoro-15-crown-5-ether (PFCE NPs, ∼200 nm) exhibite significant 19F-MRI signal-to-noise ratio (SNR) enhancement than perfluorooctyl bromide (PFOB NPs) up to day 7 after intratracheal delivery. Alveolar macrophages (AMs) engulf PFCE NPs, become PFCE NPs-laden AMs, and then migrate into the tumor margin, resulting in increased tumor PFCE concentration and 19F-MRI signals. AMs-mediated translocation of PFCE NPs to lung draning lymph nodes (dLNs) decreases the background PFCE concentration. Our results shed light on the dynamic AMs-mediated translocation of intratracheally delivered PFC NPs for effective lung tumor visualization and reveal a pathway to develop and promote the clinical translation of an intratracheal delivery-based imaging strategy.
科研通智能强力驱动
Strongly Powered by AbleSci AI