PI3K/AKT/mTOR通路
卵巢癌
磁道(磁盘驱动器)
对偶(语法数字)
mTOR抑制剂的发现与发展
医学
癌症
卵巢
癌症研究
计算机科学
内科学
生物
信号转导
遗传学
哲学
语言学
操作系统
作者
Selanere L. Mangala,Ekta Rathi,Karthik S Udupa,Shama Prasada Kabekkodu,K. Sreedhara Ranganath Pai,Suvarna G. Kini
标识
DOI:10.2174/0109298673293028240326051835
摘要
Abstract: Ovarian cancer is one of the most familiar kinds of gynecological cancer seen in women. Though it is not as familiar as breast cancer, the survival rate for ovarian cancer is very low when compared with breast cancer. Even after being one among the familiar types, to date, there are no proper treatments available for ovarian cancer. All the treatments that are present currently show a high rate of recurrence after the treatment. Therefore, treating this silent killer from the roots is the need of the hour. PI3K/AKT/m- TOR pathway is one of the pathways that get altered during ovarian cancer. Studies are already going on for the inhibition of PI3K and mTOR separately. Efforts have been made to inhibit either PI3K or mTOR separately earlier. However, due to its side effects and resistance to the treatments available, current studies are based on the inhibition of PI3K and mTOR together. Inhibition of PI3K and mTOR simultaneously reduces the chances of negative feedback, thus decreasing the toxicity. This review contains the evolution of PI3K and mTOR drugs that are approved by the FDA and are in the trials for different cancer types, including Ovarian cancer. In this article, how a molecular targeted therapy can be made successful and free from toxicity for treating ovarian cancer is discussed. Therefore, this review paves the way for finding an effective scaffold rather than the clinical part. The scaffold thus selected can be further modified and synthesized in the future as dual PI3K/mTOR inhibitors specifically for OC.
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