LRP1型
转基因小鼠
神经炎症
淀粉样前体蛋白
低密度脂蛋白受体
转基因
基因沉默
早老素
淀粉样蛋白(真菌学)
脑淀粉样血管病
BACE1-AS系列
生物
痴呆
医学
内分泌学
脂蛋白
阿尔茨海默病
内科学
病理
疾病
胆固醇
生物化学
基因
标识
DOI:10.1016/j.neulet.2023.137159
摘要
Alzheimer's disease (AD) is the most common cause of dementia worldwide. Our previous study revealed that bone morphogenetic protein 9 (BMP9) could ameliorate the amyloid pathology and cognitive impairments in a transgenic model of AD. However, the mechanisms underlying the protective effect of BMP9 against amyloid pathology remain unknown. Low-density lipoprotein receptor-related protein 1 (LRP1) plays an essential role in the clearance of amyloid beta. Here, we demonstrated that intranasal BMP9 significantly enhanced the expression of LRP1 in the brains of APP/PS1 mice. Importantly, silencing LRP1 significantly promoted the amyloid plaques accumulation and facilitated the neuroinflammation in the brains of BMP9-treated APP/PS1 mice. Furthermore, silencing LRP1 significantly impaired the learning and memory functions of BMP9-treated APP/PS1 mice. Our results suggest that BMP9 ameliorate the amyloid pathology and cognitive dysfunction in APP/PS1 mice by promoting the expression of LRP1.
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