壳聚糖
自愈水凝胶
药物输送
化学
姜黄素
纤维素
控制释放
盐酸阿霉素
石墨烯
高分子化学
化学工程
材料科学
阿霉素
傅里叶变换红外光谱
核化学
生物相容性
组合化学
纳米技术
有机化学
生物化学
外科
化疗
工程类
医学
作者
Sakineh Omidi,Mozhgan Pirhayati,Ali Kakanejadifard
标识
DOI:10.1016/j.carbpol.2019.115745
摘要
Hydrogels are promising carriers for the controlled drug delivery in response to the external stimuli such as pH and temperature. Here, a new hydrogel is designed and synthesized from the cross-linking of graphene, chitosan, and cellulose nanowhisker via Schiff base reaction by a synthetic dialdehyde. The hydrogel presented a flexible structure and responded to altering pH and adding the external stimuli such as benzaldehyde and amino acid cysteine. The synthesized hydrogel was stable under physiological conditions. In vivo test showed that the hydrogel is subcutaneously injectable. Three drug-loaded hydrogels were synthesized, and in vitro drug release study showed a pH-dependent release of drugs in PBS solution.
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