生物
巨噬细胞
背景(考古学)
免疫系统
功能(生物学)
利基
适应(眼睛)
身份(音乐)
炎症
个体发育
胚胎干细胞
细胞生物学
免疫学
遗传学
神经科学
生态学
古生物学
物理
基因
体外
声学
作者
Camille Blériot,Svetoslav Chakarov,Florent Ginhoux
出处
期刊:Immunity
[Elsevier]
日期:2020-06-01
卷期号:52 (6): 957-970
被引量:292
标识
DOI:10.1016/j.immuni.2020.05.014
摘要
Resident tissue macrophages (RTMs) have a broad spectrum of immune- and non-immune-related tissue-supporting activities. The roots of this heterogeneity and versatility are only beginning to be understood. Here, we propose a conceptual framework for considering the RTM heterogeneity that organizes the factors shaping RTM identity within four cardinal points: (1) ontogeny and the view that adult RTM populations comprise a defined mixture of cells that arise from either embryonic precursors or adult monocytes; (2) local factors unique to the niche of residence, evolving during development and aging; (3) inflammation status; and (4) the cumulative effect of time spent in a specific tissue that contributes to the resilient adaptation of macrophages to their dynamic environment. We review recent findings within this context and discuss the technological advances that are revolutionizing the study of macrophage biology.
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