Differences in clinical characteristics of idiopathic benign paroxysmal positional vertigo according to the serum vitamin D status (4195)

Objective: To evaluate whether the serum vitamin D level made clinical differences in idiopathic benign paroxysmal positional vertigo (BPPV). Background: BPPV is the most common peripheral vestibular disorders caused by dislodged otoconia composed of calcium carbonate. Vitamin D is known to be associated with homeostasis in the calcium metabolism of the otolith organ. Several studies have reported that vitamin D deficiency is a risk factor for idiopathic BPPV and influence on the recurrence rate of BPPV. However, no study to date has compared clinical characteristics in idiopathic BPPV depending on the serum vitamin D levels. Design/Methods: A total of 117 consecutive BPPV patients were enrolled between January 2017 and June 2019. The diagnosis of BPPV was based on the diagnostic criteria of BPPV suggested by the Barany Society. Patients with a history of inner ear diseases, head trauma, or other vestibular disorders (e.g., vestibular neuritis) were excluded. Based on serum vitamin D level, we divided study population into two subgroups, ‘normal group (> 50 nmol/L) and deficient group (≥50 nmol/L). Demographic, clinical characteristics and treatment outcome were compared between the two groups. Results: Vitamin D deficiency was found in 73 patients (62.4 %). The mean age, gender and subtype of BPPV (i.e., posterior canal-BPPV, horizontal canal-BPPV), and success rate of canalith repositioning maneuver (CRM) were not different between the two groups. However, BPPV patients with vitamin D deficiency required much more sessions of CRM for the successful treatment (normal group=2.0±1.01, deficient group=2.47±1.07, p=0.037). Conclusions: From our results, vitamin D deficiency seems to have little effect on clinical characteristics of idiopathic BPPV. However, more CRM sessions for treatment in vitamin D deficiency suggests that vitamin D deficiency may influence on the character of dislodged otolithic debris. Disclosure: Dr. Im has nothing to disclose. Dr. Kim has nothing to disclose. Dr. Lee has nothing to disclose.