炎症
G蛋白偶联受体
传出细胞增多
脂质信号
受体
免疫系统
神经科学
免疫学
计算生物学
生物
医学
生物信息学
巨噬细胞
生物化学
体外
作者
Margherita Mastromarino,Enza Lacivita,Nicola Antonio Colabufo,Marcello Leopoldo
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2021-01-14
卷期号:20 (20): 2090-2103
被引量:8
标识
DOI:10.2174/1389557520666200719014433
摘要
Dysregulated inflammation is a central pathological process in diverse disease states, including neurodegenerative disorders. The recent concept of “resolution of inflammation” is offering a conceptual change for the diagnosis and the development of new therapeutic approaches for chronic inflammatory diseases. Resolution of inflammation terminates the inflammatory response promoting the return to tissue homeostasis through the action of several classes of mediators, termed specialized pro-resolving lipid mediators (SPMs), that include lipoxins, resolvins, protectins, and maresins. SPMs provide “stop signals” that reduce the number of immune cells at the site of insult and increase the clearance of apoptotic cells through phagocytosis. SPMs elicit their effects through the interaction with specific G-protein coupled receptors (GPCRs). The elucidation of the pathways downstream of the GPCRs involved in the resolution of chronic inflammation is opening novel opportunities to generate novel anti-inflammatory agents. This review focuses on the SPMs and the receptors through which their effects are mediated. The medicinal chemistry of the modulators of the GPCRs involved in the resolution of inflammation will be illustrated, by highlighting the potential for developing new antiinflammatory drugs.
科研通智能强力驱动
Strongly Powered by AbleSci AI