农奴
塔普斯加尔金
内质网
化学
ATP酶
钙
钙ATP酶
生物化学
细胞生物学
酶
药理学
生物
有机化学
作者
Lucie Peterková,Eva Kmonı́čková,Tomáš Ruml,Silvie Rimpelová
标识
DOI:10.1021/acs.jmedchem.9b01509
摘要
The sarco/endoplasmic reticulum calcium ATPase (SERCA), which plays a key role in the maintenance of Ca2+ ion homeostasis, is an extensively studied enzyme, the inhibition of which has a considerable impact on cell life and death decision. To date, several SERCA inhibitors have been thoroughly studied and the most notable one, a derivative of the sesquiterpene lactone thapsigargin, is gradually approaching a clinical application. Meanwhile, new compounds with SERCA-inhibiting properties of natural, synthetic, or semisynthetic origin are being discovered and/or developed; some of these might also be suitable for the development of new drugs with improved performance. This review brings an up-to-date comprehensive overview of recently discovered compounds with the potential of SERCA inhibition, discusses their mechanism of action, and highlights their potential clinical applications, such as cancer treatment.
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