脂多糖
糖苷
体外
促炎细胞因子
化学
生物化学
消炎药
生物
立体化学
药理学
炎症
免疫学
作者
Longfei Yang,Li Teng,Yuehui Huang,Min Tang,Wan Liao,Qiang Fu
出处
期刊:Phytochemistry
[Elsevier]
日期:2022-04-01
卷期号:196: 113101-113101
被引量:3
标识
DOI:10.1016/j.phytochem.2022.113101
摘要
Six undescribed compounds, including four undescribed ecdysteroids (cyathsterones A-D) and two undescribed phenolic glycosides (cyathglucosides A-B), were isolated from the roots of Cyathula officinalis Kuan. Their structures were based on chemical analyses, NMR spectroscopic evidence, DP4+ calculations, and hydrolysis products. All compounds inhibited NO release in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages in vitro. Among them, cyathsterone A showed the strongest inhibitory effects. Moreover, cyathsterone A has been shown to inhibit the release of the proinflammatory cytokines TNF-α, IL-6, and IL-1β in LPS-induced RAW 264.7 macrophages in vitro. Further studies found that cyathsterone A present concentration-dependent suppression of the protein expression of iNOS and COX-2 in LPS-stimulated RAW 264.7 cells in vitro and exerted anti-inflammatory activity via the NF-κB signalling pathway.
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