生物膜
抗生素
微生物学
抗菌剂
胞外聚合物
药物输送
医学
药品
粘液
细菌
生物
纳米技术
药理学
材料科学
生态学
遗传学
作者
Li Zhang,Hriday Bera,Hengzhuang Wang,Junwei Wang,Yanzhu Guo,Changzhi Shi,Dongmei Cun,Claus Moser,Niels Høiby,Mingshi Yang
标识
DOI:10.1016/j.ijpharm.2022.121507
摘要
Respiratory infections are one of the major global health problems. Among them, chronic respiratory infections caused by biofilm formation are difficult to treat because of both drug tolerance and poor drug penetration into the complex biofilm structure. A major part of the current research on combating respiratory biofilm infections have been focused on destroying the matrix of extracellular polymeric substance and eDNA of the biofilm or promoting the penetration of antibiotics through the extracellular polymeric substance via delivery technologies in order to kill the bacteria inside. There are also experimental data showing that certain inhaled antibiotics with simple formulations can effectively penetrate EPS to kill surficially located bacteria and centrally located dormant bacteria or persisters. This article aims to review recent advances in the pharmaceutical strategies for combating respiratory biofilm infections with a focus on nanotechnology-based drug delivery approaches. The formation and characteristics of bacterial biofilm infections in the airway mucus are presented, which is followed by a brief review on the current clinical approaches to treat respiratory biofilm infections by surgical removal and antimicrobial therapy, and also the emerging clinical treatment approaches. The current combination of antibiotics and non-antibiotic adjuvants to combat respiratory biofilm infections are also discussed.
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