Stereoselective formation of Z-monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem‑difluoroalkenes with lithium organoborates

A method for stereoselective construction of Z -monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem ‑difluoroalkenes in mild conditions was described. The combination of lithium organoborate and ZnBr 2 generated in situ lithium aryl zincates, which facilitates the transmetalation step of the nickel-catalyzed cross coupling reaction. A method for stereoselective construction of Z -monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem ‑difluoroalkenes in mild conditions was described. The combination of lithium organoborate ZnBr 2 generated in situ lithium aryl zincates, which facilitates the transmetalation step of the nickel-catalyzed cross coupling reaction.