对映体药物
亚砜
化学
光催化
对映选择合成
生物催化
催化作用
组合化学
有机化学
光催化
氧化还原
反应机理
作者
Sarah Bierbaumer,Luca Schermund,Alexander List,Christoph Winkler,Silvia M. Glueck,Wolfgang Kroutil
标识
DOI:10.1002/anie.202117103
摘要
The concurrent operation of chemical and biocatalytic reactions in one pot is still a challenging task, and, in particular for chemical photocatalysts, examples besides simple cofactor recycling systems are rare. However, especially due to the complementary chemistry that the two fields of catalysis promote, their combination in one pot has the potential to unlock intriguing, unprecedented overall reactivities. Herein we demonstrate a concurrent biocatalytic reduction and photocatalytic oxidation process. Specifically, the enantioselective biocatalytic sulfoxide reduction using (S)-selective methionine sulfoxide reductases was coupled to an unselective light-dependent sulfoxidation. Protochlorophyllide was established as a new green photocatalyst for the sulfoxidation. Overall, a cyclic deracemization process to produce nonracemic sulfoxides was achieved and the target compounds were obtained with excellent conversions (up to 91 %) and superb optical purity (>99 % ee).
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