卡路里
内科学
内分泌学
热卡限制
肾小球疾病
肥胖
肾脏疾病
斑马鱼
疾病
生物
肾
生理学
医学
蛋白尿
生物化学
基因
作者
Evan M. Zeitler,J. Charles Jennette,Jennifer E. Flythe,Ronald J. Falk,Joanna Poulton
出处
期刊:American Journal of Physiology-renal Physiology
[American Physiological Society]
日期:2022-05-01
卷期号:322 (5): F527-F539
被引量:4
标识
DOI:10.1152/ajprenal.00018.2022
摘要
Obesity is a risk factor for kidney disease. The role of diet in this association is difficult to study in humans. In this study, zebrafish fed a high-calorie diet, regardless of fat macronutrient composition, developed glomerulomegaly, foot process effacement, and filtration barrier dysfunction, recapitulating the changes seen in humans with obesity. Calorie restriction reversed the changes. This work suggests that macronutrient composition may be less important than total calories in the development of obesity-related kidney disease.
科研通智能强力驱动
Strongly Powered by AbleSci AI