癌变
转移
生物
自噬
癌症研究
癌症
小RNA
血管生成
上皮-间质转换
细胞凋亡
癌症干细胞
基因
遗传学
作者
Cheng Zheng,Maoping Chu,Qiuli Chen,Cheng Chen,Zhi-wei Wang,Xiao Chen
出处
期刊:Apoptosis
[Springer Nature]
日期:2022-03-22
卷期号:27 (5-6): 311-321
被引量:11
标识
DOI:10.1007/s10495-022-01722-3
摘要
OIP5-AS1, a conserved lncRNA, has been reported to be involved in several biological and pathological processes, including oncogenesis. OIP5-AS1 exerts its oncogenic or antitumor functions via regulation of different miRNAs in various cancer types. In this review, we describe the dysregulation of OIP5-AS1 expression in a variety of human cancers. Moreover, we discuss the multiple functions of OIP5-AS1 in cancer, including in proliferation, apoptosis, autophagy, ferroptosis, cell cycle, migration, metastasis, invasion, epithelial to mesenchymal transition, angiogenesis, cancer stem cells and drug resistance. Furthermore, we provide a future perspective for OIP5-AS1 research. We conclude that targeting OIP5-AS1 might be a promising cancer therapy approach.
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