化学
烷基化
激进的
组合化学
DNA
胺气处理
卤化物
有机化学
生物化学
催化作用
作者
Yurong Shen,Ge Yang,Wei Huang,Alex Shaginian,Qian Lin,Jinqiao Wan,Jin Li,Yun Deng,Guansai Liu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-04-01
卷期号:24 (14): 2650-2654
被引量:13
标识
DOI:10.1021/acs.orglett.2c00697
摘要
Herein, we report an on-DNA photoredox-mediated deaminative alkylation method for diversifying DNA-tagged acrylamide substrate with amine-derived radicals. The radicals can be conveniently generated from sterically hindered primary amines, and the deaminative alkylation can tolerate a broad array of radical precursors. Furthermore, the methodology is applicable to Boc-protected diamines, free amino acids, and aryl halides, which bear functional groups enabling additional rounds of diversification. The method is believed to offer a high potential for constructing DNA-encoded libraries, as was demonstrated by the production of a mock library in a 2 × 3 matrix format and confirmation of DNA stability by UPLC-MS and qPCR experiments.
科研通智能强力驱动
Strongly Powered by AbleSci AI