化学
对映选择合成
电泳剂
镍
联轴节(管道)
碳纤维
偶联反应
药物化学
组合化学
高分子化学
催化作用
有机化学
材料科学
冶金
复合数
复合材料
作者
Ziqi Zhu,Lin Lin,Jieshuai Xiao,Zhuangzhi Shi
出处
期刊:Angewandte Chemie
[Wiley]
日期:2021-12-10
卷期号:61 (6): e202113209-e202113209
被引量:64
标识
DOI:10.1002/anie.202113209
摘要
Stereo- and enantioselective cross-electrophile coupling involving C-F bond activation is reported. Treatment of gem-difluoroalkenes with racemic benzyl electrophiles in the presence of a chiral nickel complex using B2 pin2 as a stoichiometric reductant allows the construction of a C(sp2 )-C(sp3 ) bond under mild conditions, affording a broad range of monofluoroalkenes bearing stereogenic allylic centers. Initial mechanistic studies indicate that a radical chain pathway may be operating, wherein the ester group in the gem-difluoroalkene promotes C-F bond activation through oxidative addition to a Ni species.
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