Efficacy and safety of intravenous cyclophosphamide pulse therapy with oral prednisolone in the treatment of interstitial lung disease with systemic sclerosis: 4-year follow-up

医学 间质性肺病 泼尼松龙 内科学 环磷酰胺 支气管肺泡灌洗 高分辨率计算机断层扫描 肺功能测试 胃肠病学 痹症科 化疗
作者
Akiko Tochimoto,Yasushi Kawaguchi,Masako Hara,Mutsuto Tateishi,Chikako Fukasawa,Kae Takagi,Emi Nishimagi,Yukiko Ota,Yasuhiro Katsumata,Takahisa Gono,Eiichi Tanaka,Hisashi Yamanaka
出处
期刊:Modern Rheumatology [Informa]
卷期号:21 (3): 296-301 被引量:16
标识
DOI:10.3109/s10165-010-0403-6
摘要

Interstitial lung disease (ILD) is a noteworthy condition in the treatment of systemic sclerosis (SSc) because of its associated mortality and morbidity; however, the efficacy of various treatments for ILD has been controversial in previous reports. In this study, we examined the efficacy and safety of intravenous cyclophosphamide (IVCY) pulse therapy with prednisolone (PSL) for the treatment of ILD with SSc. A total of 121 patients with SSc were screened and evaluated for ILD, using high-resolution computed tomography of the chest, pulmonary function testing, and bronchoalveolar lavage. Thirteen patients with active ILD were enrolled in this study. The treatment protocol for ILD was 0.4 g/m2 of body surface area of IVCY monthly plus 0.8 mg/kg of body weight of PSL daily. Two to six doses of IVCY were administered, depending on the remission of ILD. Initial PSL doses were maintained for a month and then gradually tapered to 10 mg daily. An activity index of ILD showed improvements in all patients in the 12 months after the initial intervention; however, four patients experienced recurrence of ILD after 24 months, and one additional patient had recurrence of ILD after 36 months. Seven patients reached the 48-month point with no recurrence of ILD. This long observational study for 48 months showed the efficacy of IVCY with PSL for active alveolitis in the first year. However, because five patients had recurrence of ILD more than 1 year after the treatment, it would be necessary to consider maintenance therapy for ILD beyond 1 year.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
用户123发布了新的文献求助10
2秒前
2秒前
3秒前
4秒前
Jocelyn12完成签到,获得积分10
4秒前
CipherSage应助Linda采纳,获得10
4秒前
Jocelyn12发布了新的文献求助10
6秒前
ziyou发布了新的文献求助10
7秒前
uhcxishaj发布了新的文献求助10
7秒前
10秒前
10秒前
李爱国应助大碗采纳,获得10
11秒前
YYJ25完成签到,获得积分10
11秒前
田様应助被划分采纳,获得10
12秒前
仁爱尔槐完成签到 ,获得积分10
12秒前
tunerling发布了新的文献求助10
13秒前
我还能学发布了新的文献求助10
13秒前
13秒前
14秒前
在水一方应助小梨崽崽采纳,获得10
14秒前
15秒前
16秒前
1226发布了新的文献求助10
17秒前
ziyou完成签到,获得积分10
18秒前
19秒前
19秒前
20秒前
21秒前
AAA发布了新的文献求助10
22秒前
23秒前
ChJia发布了新的文献求助10
23秒前
大碗发布了新的文献求助10
24秒前
24秒前
隐形曼青应助科研通管家采纳,获得10
24秒前
FashionBoy应助科研通管家采纳,获得10
24秒前
wanci应助科研通管家采纳,获得10
24秒前
今后应助科研通管家采纳,获得10
25秒前
newfat应助科研通管家采纳,获得30
25秒前
英姑应助科研通管家采纳,获得10
25秒前
高分求助中
One Man Talking: Selected Essays of Shao Xunmei, 1929–1939 1000
Yuwu Song, Biographical Dictionary of the People's Republic of China 700
[Lambert-Eaton syndrome without calcium channel autoantibodies] 520
Sphäroguß als Werkstoff für Behälter zur Beförderung, Zwischen- und Endlagerung radioaktiver Stoffe - Untersuchung zu alternativen Eignungsnachweisen: Zusammenfassender Abschlußbericht 500
少脉山油柑叶的化学成分研究 430
Revolutions 400
MUL.APIN: An Astronomical Compendium in Cuneiform 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2454120
求助须知:如何正确求助?哪些是违规求助? 2126033
关于积分的说明 5414461
捐赠科研通 1854720
什么是DOI,文献DOI怎么找? 922437
版权声明 562326
科研通“疑难数据库(出版商)”最低求助积分说明 493552