The Role of Geftinat in Non Small Cell Lung Cancer Induced by Autophagy

Objective: To observe The role of Geftinat in non small cell lung cancer induced by autophagy and to investigate the mechanism. Methods: 40 nude mice were randomly divided into two groups, the group with geftinat was treated by infusing the stomach with the medicine, 25mg/kg. The expression of Beclin1 and MAPLC3 were determined by immunofluorescence, RT-PCR and Western blot. Results: The Mrna and protein level of Beclin1 and MAPLC3 in the group with geftinat treating were both significant higher by immunofluorescence, RT-PCR and Western blot. Conclusion: Geftinat can inhibit the progress of non small cell lung cancer by influence autophagy.