With fermentative mushroom residue good as raw material,according to the different volume ratio were applied into soil,lettuce pot test,to investigate the effect of application of mushroom residue on growth and development of soil properties and lettuce.The results showed that after the application of mushroom residue,soil physical and chemical properties was improved obviously,soil organic matter,nitrogen phosphorus and potassium content of three elements was improved,when mushroom residue and soil ratio was 1∶2,area of the lettuce leaves was the largest,when mushroom residue and soil ratio was 1∶1,yield of lettuce was the highest.