部分
化学
聚酮
立体化学
丙二酸
生物合成
抗生素
缬氨酸
链霉菌
生物化学
细菌
氨基酸
酶
遗传学
生物
作者
Kerstin Herold,Zhongli Xu,Friedrich A. Gollmick,U. Gräfe,Christian Hertweck
摘要
Cervimycin C is the major component of an antibiotic complex produced by Streptomyces tendae HKI-179 consisting of a tetracycline-type aglycon, six tridesoxysugars and a rare dimethylmalonyl moiety. The biosynthetic origin of cervimycin was studied by molecular studies and feeding experiments, which reveal that the dimethylmalonate unit is not derived from malonate, but from valine.
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