肠道通透性
色氨酸
锌
维生素C
抗氧化剂
紧密连接
维生素
化学
肠粘膜
内分泌学
内科学
生物化学
生物
医学
氨基酸
有机化学
作者
N A Basova,Iu G Markov,N. I. Berzin
出处
期刊:PubMed
日期:2002-05-01
卷期号:88 (5): 650-7
被引量:1
摘要
The main concern of this work was to examine the relation between altered antioxidant status on the one hand and increase in L-tryptophan absorption in the small intestine in order to bring further information regarding to possible role of vitamin A and zinc to maintaining of intestinal epithelial barrier integrity, on the other hand. In control, only some ideal tight junctions at the tip of the villi were permeable to ZnC1(2), whereas in A-hypovitaminosis permeability increased significantly. Studies demonstrate that an increased L-tryptophan accumulation in the intestinal mucous may result from a free radical damage to the mucous surface with formation of "leaky" junctions in the ilea. The results suggest that the zinc plays a crucial role in stabilizing biomembranes.
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